It is commonly used to reduce minor pain and aches analgesiclower fever antipyreticthin the blood anticoagulationreduce the inflammation such as Chemistry of aspirin essay and arthritis anti-inflammatoryenhances the elimination of uric acid uricosuric and reduce the risk of stroke, heart attack and other heart problems in long-term low-doses.
Yet the actual yield was only 1. The mixture was stirred and rubbed with stirring rod if necessary to induce crystallization.
This due to the many sources of error present in the lab. The calculations for the theoretical yield and the percent yield can be seen in the results section above.
If a solid separates out at this point, the solution is warmed until solid dissolves completely. While it is hot, about 1 ml of distilled water was cautiously added from a dropper to decompose the excess acetic anhydride.
This gives a low percentage yield of only Crystallization is one of the method used to separate esters from the mixture. The obvious remedy to this problem is to pay attention and try to do the lab work precisely. Another source of error is not allowing enough time for the aspirin to recrystallize and precipitate in the ice bath.
Approximately 30 ml of hot water was added to the solution. If one does not dry the paper enough, then the residual moisture on the filter paper could make the weight measurements inaccurate. The melting point of aspirin was determined by melting point meter.
Synthesis of aspirin involves two steps, which are isolation and recrystallisation. An additional source of error can occur during the drying of the filter paper in step 5 of the lab manual3 page The related compound of aspirin from willow bark Salix alba has been used to relieve pain and reduce fever since hundred of years a go.
A simple solution to this is allowing the aspirin to recrystallize for a longer period without disturbance. The most important component in recrystallisation is the solvent used as it has to be able to dissolve the aspirin near its boiling point so that the crystals can be form during the cooling leaving the impurities dissolved.
InGerman researchers also isolated the compound from meadowsweet flowers. Sometimes, the best recrystallisation solvent is a mixture of two miscible solvents, one which dissolves the compound readily, the other which does not 5.
This would dissolve the aspirin into solution and make it much more difficult for us to collect and measure the aspirin. In this experiment a mixed solvent of ethanol and water was used as aspirin is very soluble in ethanol but quite insoluble in water 5. The method used to synthesize aspirin was esterification by reacting salicylic acid with acetic anhydride with the presence of dehydrating agent, conc.
Another solution is that in step 5 of the lab3 page 44 one could try to wash down the aspirin with four small 5mL portions of water rather than two large 10 mL portions as stated in the lab manual.
The solution was cooled. Having filtered, cold water was used to wash the crude aspirin to isolate the most of the impurities leaving the crude product and pure solvent on the filter paper. It is warmed on a hot plate if necessary ii. Three or four drops of conc.
Get Full Essay Get access to this section to get all help you need with your essay and educational issues. This makes it easier for us to filter and collect the aspirin solid. From the reaction equation located in the Introduction of this report one mole of Salicylic acid reacts with one mole of acetic anhydride to form product.
Warm water would increase the kinetic energy of the aspirin molecules, increase their vibrational speed, and break their crystal structures. This experiment allowed the students to conduct the synthesis of aspirin, acquire the skills of recrystallisation using normal filtration and reinforce the technique of the melting point determination.
Since there are fewer moles of salicylic acid relative to acetic anhydride see Calculation 5 abovethe amount of product that can be formed depends on the amount of Salicylic acid, making it the limiting reagent. For example, residual amounts of aspirin were left over on many of the equipment used, especially on stir rods and the inside of flasks.
Then, the crude aspirin is purified by recrystallisation. One could also add more ice to the ice bath which would cool the solution further and allow precipitate to form faster.
A solvent convenient for this crystallization process was a mixture of ethanol and water. The chemical equation 4 The symbolic equation In this reaction, the -OH group from salicylic acid is substituted with -COOH group from acetic anhydride to form ester while the carboxylic acid group of salicylic acid remains unchanged.
The theoretical yield of aspirin expected from 2. This would mean that some of the aspirin would be dissolved in solution and not be caught by the filter.Acetylsalicylic Acid (Aspirin) Synthesis Telow, AJV Sumicad, CJ, Tavanlar, EMMT, ChemInstitute of Chemistry, University of the Philippines Los Baños I.
Introduction Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials. Aspirin is a derivative of salicylic acid that is a mild, nonnarcotic analgesic useful in the relief of headache and muscle and joint aches.
It is also useful in organic chemistry for the test of alcohols and carboxylic acid. It is used in polymer industry. If you are the original writer of this essay and no longer wish to have the. Inorganic and Organic Chemistry – Preparation and Recrystallisation of Aspirin Essay Sample The purpose of this experiment was for students to prepare some simple organic compound and to purify the compound by recrystallisation.
It was known that aspirin had some side effects that were caused by the level of acid in the aspirin itself, which made the stomach irate when ingested. Hoffman reduced the acid by mixing the aspirin with sodium salicylate, a extract found in the willow tree bark , which paved the way to today's most popular and inexpensive drug .
Synthesis of Aspirin Lab Report; Synthesis of Aspirin Lab Report. Words Mar 3rd, 12 Pages. Essay on Synthesis of Aspirin Words | 22 Pages. The Synthesis of Aspirin Chemistry Standard Level Lab Report Data Collection and Processing and Conclusion and Evaluation Date: December 8th, Purpose: The purpose of this.
Free aspirin papers, essays, and research papers. for the Boots Company in the s when looking for an alternative with fewer side effects than the commonly prescribed aspirin (The Royal Society of Chemistry, ).
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